Which phase is associated with angiogenesis and granulation tissue formation?

Which phase is associated with angiogenesis and granulation tissue formation?

• A. 1st phase
• B. 2nd phase
• C. 3rd phase
• D. 4th phase

Answer: (B)

The proliferative phase is when new tissue is built to replace what was damaged. During this phase, angiogenesis occurs as new blood vessels form to supply the growing tissue, while fibroblasts lay down extracellular matrix to create granulation tissue. This granulation tissue fills the wound bed, supports epithelial cells as they migrate across the surface, and provides a vascular bed for ongoing healing. In contrast, the inflammatory phase focuses on cleaning debris and fighting infection, and the remodeling phase later reorganizes collagen to increase tensile strength. So the combination of new blood vessel growth and granulation tissue formation is characteristic of the proliferative (second) phase.

The proliferative phase is when new tissue is built to replace what was damaged. During this phase, angiogenesis occurs as new blood vessels form to supply the growing tissue, while fibroblasts lay down extracellular matrix to create granulation tissue. This granulation tissue fills the wound bed, supports epithelial cells as they migrate across the surface, and provides a vascular bed for ongoing healing. In contrast, the inflammatory phase focuses on cleaning debris and fighting infection, and the remodeling phase later reorganizes collagen to increase tensile strength. So the combination of new blood vessel growth and granulation tissue formation is characteristic of the proliferative (second) phase.